Juana (November 6, 1479 – April 12, 1555), known historically as Joanna the Mad (Spanish: Juana la Loca), was the Queen of Castile from 1504, and of Aragon from 1516. Modern Spain evolved from the union of these two crowns. Joanna was married by arrangement to Philip the Handsome, Archduke of the House of Habsburg, on October 20, 1496. Following the deaths of her brother, John, Prince of Asturias, in 1497, her elder sister Isabella in 1498, and her nephew Miguel in 1500, Joanna became the…